Stem cell drugs: the next generation of pharmaceutical products

Expected Next-Generation Drugs

Insights into the next generation of cancer stem cell research.

The understanding of how cancer stem cells (CSCs) or tumor-initiating cells (TICs) behave is important in understanding how tumors are initiated and how they recur following initial treatment. More specifically to understand how CSCs behave, the different signaling mechanisms orchestrating their growth, cell cycle dynamics, differentiation, trans-differentiation and survival following cytotoxic...

Dear student: stem cell scientists' advice to the next generation.

For the field of pluripotent stem cell biology to realize its promising future, current researchers will need to pass the torch to new generations. We asked a group of successful scientists in this area, "What advice would you give a young person considering a career in stem cell research?"

Anticipating a next-generation census of stem-cell small RNA

Anew generation of technology promises a future of fast and cheap DNA and RNA sequencing by simultaneously analyzing millions of nucleic acid molecules. Graced with names such as “ultra highthroughput” or “next-generation” sequencing, this technological revolution actually consists of several competing technologies that allow large surveys of nucleic-acid samples — both genomic DNA and RNA tran...

Hypercholesterolaemia: optimal treatment by next-generation drugs?

ticular, homozygous autosomal dominant hypercholesterolaemia, an orphan disease caused by mutations in the LDL receptor, apolipoprotein B (APOB), or PCSK9, is characterised by elevated LDL-C levels [8]. At the same time as the approval of evolocumab, the US Food and Drug Administration (FDA) approved another PCSK9 inhibitor, alirocumab (Praluent) produced by Sanofi and Regeneron. Alirocumab was...